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AASCIT Communications | Volume 3, Issue 3 | May 13, 2016 online | Page:169-176
Cyclic Voltammetry Study of Copper Chloride Salt with Ceftazidime Antibiotic
Abstract
The interaction of copper chloride salt with Ceftazidime antibiotic has been studied using cyclic voltammetric technique in the potential range (+1.5 to -1.0) V at a scan rate 50 (mV/s) with mixed (MeOH+H2O) using NaClO4 (0.3M) as supporting medium and platinum as a working electrode at 298.15K. The voltammetry pattern of the blank medium didn't show any significant peak during the anodic and cathodic scans in the selected potential range while the peaks of the free metal ions clearly indicates a stripping anodic peak at ≈ 0.1V vs SCE (0.342 V vs NHE). This peak is due to the dissolution of metallic copper deposited during the cathodic scan between -0.1 to -0.5 V. The results of interactions of CuCl2.2H2O with CFZ in the ratio (1:1) and (1:2) are displayed and show regular decrease of the anodic peaks as a result of complexation of Cu ions with CFZ. In conclusion, both CFZ and alcohol had affected Cu ions deposition. The redox mechanism was explained also. The aim of the work is to estimate the stability constant and free energy of interaction between copper and the drug.
Authors
[1]
E. A. Gomaa, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
[2]
S. E. Salem, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Keywords
Ceftazidime Antibiotic (CFZ), Copper Chloride Salt (CuCl2.2H2O), Cyclic Voltammetry (CV), Anodic Peak Potential (∆Ep)
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Arcticle History
Submitted: Mar. 16, 2016
Accepted: Apr. 11, 2016
Published: May 13, 2016
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